Question:
Regarding gout, which of the following is the underlying metabolic basis?
Regarding gout, which of the following is the underlying metabolic basis?
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Look for the root enzymatic defect, not a complication.
Updated On: Jun 24, 2026
- Uric acid nephrolithiasis
- Deficiency of the enzyme involved in purine metabolism
- Increase in serum urate concentration
- Renal disease involving the interstitial tissues
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The Correct Option is B
Solution and Explanation
Step 1: Gout is a hereditary disorder marked by an increase in serum uric acid due to increased production or decreased excretion of uric acid and urate salts.
Step 2: It is thought to be caused by the lack of an enzyme needed to completely metabolise purines for renal excretion, which is the metabolic basis selected by the recall key (option 2).
Step 3: The resulting hyperuricaemia leads to deposition of monosodium urate crystals in joints, triggering acute inflammatory arthritis.
Step 4: Uric acid nephrolithiasis and interstitial renal disease are complications rather than the primary enzymatic cause, so options 1 and 4 are not the best basis, and option 3 is a consequence rather than the root enzymatic defect.
Step 2: It is thought to be caused by the lack of an enzyme needed to completely metabolise purines for renal excretion, which is the metabolic basis selected by the recall key (option 2).
Step 3: The resulting hyperuricaemia leads to deposition of monosodium urate crystals in joints, triggering acute inflammatory arthritis.
Step 4: Uric acid nephrolithiasis and interstitial renal disease are complications rather than the primary enzymatic cause, so options 1 and 4 are not the best basis, and option 3 is a consequence rather than the root enzymatic defect.
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