Question

Primary uterine inertia can be treated with

• A. Estrogen
• B. Progesterone
• C. Prostaglandin F2\(\alpha\)
• D. Combination of oxytocin and calcium

Hint:

Primary Uterine Inertia Medical Protocol: 1. $10\%$ Calcium Gluconate (restores myometrial tone) $+$ 2. Low-dose Oxytocin (stimulates contraction). NEVER use if obstructive dystocia is present.

Answer 1

The Correct Option is D

Step 1: Understanding the Concept:
Therapeutic management of canine and feline maternal dystocia due to primary hypocalcemic/hypocontractile uterine inertia.

Step 2: Detailed Explanation:
Medical management of Primary Uterine Inertia (failure of the pregnant myometrium to initiate or sustain normal labor contractions):
- Requires verification of normal birth canal patency (no obstructive fetal dystocia).
- Standard medical protocol combines:
1. $10\%$ Calcium Borogluconate Calcium Gluconate (slowly i/v or s/c): Increases intracellular sarcoplasmic $\text{Ca}^{2+}$ reserves to strengthen the contractile machinery of myometrial smooth muscle.
2. Oxytocin (low-dose protocol, $0.5 - 2\text{ IU}$ i/m): Binds myometrial oxytocin receptors to stimulate rhythmic, coordinated uterine contractions.
- Administering calcium first sensitizes myometrial receptors to oxytocin, optimizing efficacy.

Step 3: Final Answer:
Therefore, primary uterine inertia is treated with a Combination of oxytocin and calcium, matching option (D).