Question

Name any two types of antibodies found to give humoral immune response in humans.

Hint:

Name the antibody that appears first in a primary response and the antibody that is most abundant in blood. Both are immunoglobulins involved in humoral immunity.

Answer 1

Step 1: Understanding the Concept:
Antibodies, or immunoglobulins (Ig), are Y-shaped proteins produced by plasma cells to neutralize pathogens.
Step 2: Detailed Explanation:
There are five main classes of antibodies in humans, abbreviated as GAMED:
1. IgG: The most abundant antibody in the blood; it can cross the placenta.
2. IgM: Usually the first antibody produced during a primary immune response.
3. IgA: Found in secretions like saliva, tears, and colostrum (first milk).
4. IgE: Involved in allergic reactions and defense against parasites.
5. IgD: Primarily acts as an antigen receptor on B-cell surfaces.
Any two of these can be mentioned as participants in the humoral response.
Step 3: Final Answer:
Two types of antibodies are IgG and IgM.

Answer 2

Concept:

• Humoral immunity is carried out by immunoglobulins secreted by plasma cells.
• Different antibody classes dominate different stages or locations of the immune response.

Step 1: Choose an antibody from the primary response.
IgM is usually the first major antibody produced when the body encounters an antigen for the first time.

Step 2: Choose an antibody from later circulation.
IgG is the most abundant antibody in blood and is important in the secondary immune response and long-term protection.

Step 3: Confirm that both belong to humoral immunity.
Both IgM and IgG bind antigens as soluble antibodies and help neutralise or remove pathogens. Therefore, either can be named as a humoral-response antibody.

Final Answer: IgM and IgG.