Question:
Mycoplasma is resistant to which of the following?
Mycoplasma is resistant to which of the following?
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No cell wall means cell-wall drugs are useless - pick the beta-lactam.
Updated On: Jun 23, 2026
- Ceftriaxone
- Cephalosporins
- Aminoglycosides
- Fluoroquinolones
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The Correct Option is A
Solution and Explanation
Step 1: Recall the key feature of Mycoplasma. Mycoplasma species lack a cell wall, so any antibiotic that works by inhibiting cell wall synthesis is intrinsically ineffective.
Step 2: Apply this to the options. Ceftriaxone is a third generation cephalosporin, a beta-lactam whose target is the bacterial cell wall. With no wall to attack, Mycoplasma is naturally resistant to it.
Step 3: Select the answer. Option a, ceftriaxone, is the drug Mycoplasma resists.
Step 4: Contrast with the effective drugs. Macrolides, tetracyclines, and fluoroquinolones target the ribosome or DNA gyrase, not the wall, so they are first-line for Mycoplasma pneumoniae. Aminoglycosides also act on the ribosome. The single best beta-lactam answer matching the stem is ceftriaxone. Note that the option "cephalosporins" as a class is also wall-active, but ceftriaxone is the specific intended key.
Step 2: Apply this to the options. Ceftriaxone is a third generation cephalosporin, a beta-lactam whose target is the bacterial cell wall. With no wall to attack, Mycoplasma is naturally resistant to it.
Step 3: Select the answer. Option a, ceftriaxone, is the drug Mycoplasma resists.
Step 4: Contrast with the effective drugs. Macrolides, tetracyclines, and fluoroquinolones target the ribosome or DNA gyrase, not the wall, so they are first-line for Mycoplasma pneumoniae. Aminoglycosides also act on the ribosome. The single best beta-lactam answer matching the stem is ceftriaxone. Note that the option "cephalosporins" as a class is also wall-active, but ceftriaxone is the specific intended key.
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