Question:
Most preferable antidote of lead poisoning is:
Most preferable antidote of lead poisoning is:
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Always remember: Calcium disodium EDTA (Calcium versenate) is the gold-standard antidote for lead toxicity in veterinary medicine.
It must be administered as calcium disodium EDTA; using plain disodium EDTA (\(\text{Na}_2\text{EDTA}\)) is contraindicated because it binds systemic calcium and causes fatal hypocalcemic tetany.
It must be administered as calcium disodium EDTA; using plain disodium EDTA (\(\text{Na}_2\text{EDTA}\)) is contraindicated because it binds systemic calcium and causes fatal hypocalcemic tetany.
Updated On: Aug 24, 2026
- Atropine sulfate
- Calcium versenate
- Dimercaptopropanol
- Activated charcoal
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The Correct Option is B
Solution and Explanation
Step 1: Understanding the Concept:
Heavy metal toxicities require specific chelating agents (antidotes) that bind to the circulating metal ions to form stable, non-toxic, water-soluble complexes that can be safely excreted in urine.
Step 2: Detailed Explanation:
Let us review the clinical applications of the listed antidotes:
- Atropine sulfate: A specific physiological antagonist used to block muscarinic receptors in organophosphate and carbamate poisoning, having no effect on heavy metals.
- Calcium versenate (Calcium disodium EDTA \(\text{Ca-Na}_2\text{EDTA}\)): This is the most effective and preferred chelating agent for treating acute and chronic lead poisoning in domestic animals.
It displaces calcium with lead, forming a highly stable, soluble lead-EDTA complex that is rapidly filtered and excreted by the kidneys.
- Dimercaptopropanol (BAL): Another chelating agent used primarily for arsenic, mercury, and gold poisoning.
While it can be used adjunctively with Ca-EDTA in severe lead encephalopathy, it is not preferred as a monotherapy due to higher toxicity.
- Activated charcoal: A general physical adsorbent that prevents gastrointestinal absorption of organic toxins but is poorly effective at adsorbing inorganic heavy metals like lead.
Step 3: Final Answer:
Therefore, Calcium versenate is the most preferred antidote for lead poisoning.
Heavy metal toxicities require specific chelating agents (antidotes) that bind to the circulating metal ions to form stable, non-toxic, water-soluble complexes that can be safely excreted in urine.
Step 2: Detailed Explanation:
Let us review the clinical applications of the listed antidotes:
- Atropine sulfate: A specific physiological antagonist used to block muscarinic receptors in organophosphate and carbamate poisoning, having no effect on heavy metals.
- Calcium versenate (Calcium disodium EDTA \(\text{Ca-Na}_2\text{EDTA}\)): This is the most effective and preferred chelating agent for treating acute and chronic lead poisoning in domestic animals.
It displaces calcium with lead, forming a highly stable, soluble lead-EDTA complex that is rapidly filtered and excreted by the kidneys.
- Dimercaptopropanol (BAL): Another chelating agent used primarily for arsenic, mercury, and gold poisoning.
While it can be used adjunctively with Ca-EDTA in severe lead encephalopathy, it is not preferred as a monotherapy due to higher toxicity.
- Activated charcoal: A general physical adsorbent that prevents gastrointestinal absorption of organic toxins but is poorly effective at adsorbing inorganic heavy metals like lead.
Step 3: Final Answer:
Therefore, Calcium versenate is the most preferred antidote for lead poisoning.
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