Question

Match the following Class and their Drug:
(1) Alkylating                       (P) 5-fluorouracil
(2) Platinum analog             (Q) Cisplatin
(3) Antimetabolite               (R) Cetuximab
(4) EGF receptor inhibitor   (S) Chlorambucil

• A. (1)-(P), (2)-(S), (3)-(Q), (4)-(R)
• B. (1)-(Q), (2)-(R), (3)-(S), (4)-(P)
• C. (1)-(S), (2)-(Q), (3)-(P), (4)-(R)
• D. (1)-(Q), (2)-(R), (3)-(P), (4)-(S)

Hint:

When matching drug classes, focus on their mechanism of action: alkylating agents modify DNA, platinum compounds crosslink DNA, antimetabolites interfere with nucleotide synthesis, and EGF inhibitors block receptor signaling.

Answer 1

The Correct Option is C

Alkylating agents such as Chlorambucil (S) work by adding alkyl groups to DNA, interfering with replication. Platinum analogs like Cisplatin (Q) form DNA crosslinks inhibiting DNA synthesis. Antimetabolites, such as 5-fluorouracil (P), inhibit nucleotide synthesis by mimicking natural metabolites. EGF receptor inhibitors, like Cetuximab (R), block epidermal growth factor receptor signaling to prevent cancer cell growth.

Hence, the correct matching is (1)-(S), (2)-(Q), (3)-(P), (4)-(R). 
 

Answer 2

This question matches four chemotherapy drug classes with representative drugs. Fix the correct drug for each class first: alkylating agents are represented by Chlorambucil (S), platinum analogs by Cisplatin (Q), antimetabolites by 5-fluorouracil (P), and EGF receptor inhibitors by Cetuximab (R). Now compare this against each option.

1. (1)-(P), (2)-(S), (3)-(Q), (4)-(R): This pairs the alkylating class with 5-fluorouracil, which is an antimetabolite, and the platinum analog class with Chlorambucil, which is an alkylating agent. Both drugs are placed against the wrong class, so this combination is wrong.
2. (1)-(Q), (2)-(R), (3)-(S), (4)-(P): This pairs the alkylating class with Cisplatin, a platinum analog, and the EGF receptor inhibitor class with 5-fluorouracil, an antimetabolite. None of these four pairs matches the drug's real class, so this combination is wrong.
3. (1)-(S), (2)-(Q), (3)-(P), (4)-(R): This pairs alkylating with Chlorambucil, platinum analog with Cisplatin, antimetabolite with 5-fluorouracil, and EGF receptor inhibitor with Cetuximab. Every drug sits with its real class, so this combination is correct.
4. (1)-(Q), (2)-(R), (3)-(P), (4)-(S): This pairs the alkylating class with Cisplatin and the EGF receptor inhibitor class with Chlorambucil, both mismatches, so this combination is wrong.

Only the third combination places every drug against the class it actually belongs to.

Therefore, the correct answer is (1)-(S), (2)-(Q), (3)-(P), (4)-(R).