Question

Match List I with List II

List I (Virus family) & List II (Budding site membrane assembly)
A. Poxviridae & I. Endoplasmic reticulum
B. Herpesviridae & II. Nuclear membrane
C. Rhabdoviridae & III. Golgi membrane de novo membrane
D. Coronaviridae & IV. Plasma membrane

Choose the correct answer from the options given below:

• A. A-IV, B-III, C-I, D-II
• B. A-III, B-IV, C-II, D-I
• C. A-III, B-II, C-IV, D-I
• D. A-II, B-III, C-I, D-IV

Hint:

Herpesvirus is the classic example of a virus that buds through the nuclear membrane, whereas Rhabdoviruses bud through the plasma membrane, and Coronaviruses bud into the ERGIC/ER.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
Enveloped viruses acquire their host-derived lipid envelope by budding through cellular membranes.
This budding occurs at specific organelle membranes where the viral glycoproteins have been targeted and assembled.
Detailed Explanation:
Let us match the viral families with their corresponding membrane assembly or budding site:
- A. Poxviridae: Unlike most enveloped viruses, Poxviruses assemble in distinct cytoplasmic areas called viral factories. They acquire their membranes inside the cytoplasm by de novo lipid synthesis or wrapping in membranes derived from the trans-Golgi network. This matches with III. Golgi membrane.
- B. Herpesviridae: These double-stranded DNA viruses assemble their nucleocapsids inside the nucleus. To exit, the capsid buds through the inner nuclear membrane into the perinuclear space, acquiring its primary envelope. This matches with II. Nuclear membrane.
- C. Rhabdoviridae: These negative-sense, single-stranded RNA viruses (such as Rabies virus) assemble their helical nucleocapsid in the cytoplasm and acquire their envelope by budding directly through the host cell's outer membrane. This matches with IV. Plasma membrane.
- D. Coronaviridae: Coronaviruses assemble and acquire their envelope by budding into the lumen of the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). This matches with I. Endoplasmic reticulum.
Therefore, the correct matches are: A-III, B-II, C-IV, D-I.

Step 2: Final Answer:
The correct combination is A-III, B-II, C-IV, D-I, corresponding to Option (C).