Question

Match List I with List II 

 

• A. A-IV, B-III, C-II, D-I
• B. A-I, B-II, C-III, D-IV
• C. A-II, B-I, C-III, D-IV
• D. A-III, B-I, C-IV, D-II

Hint:

Remember the cardiovascular endings:
- Drugs ending in "-pril" (like Captopril) are ACE inhibitors.
- Drugs ending in "-sartan" (like Losartan) are AT1 receptor antagonists.

Answer 1

The Correct Option is A

Step 1: Understanding the Concept:
Cardiovascular and vasoactive drugs act via specific receptors, enzymes, or ion channels to regulate blood pressure, vascular tone, and cardiac contractility.

Step 2: Detailed Explanation:
Let us correlate each drug with its primary pharmacological mechanism:
- A. Losartan: Blockades angiotensin II from binding to angiotensin II type 1 (AT1) receptors, acting as an AT1 receptor antagonist to promote vasodilation.
Thus, A matches with IV.
- B. Ouabain: Inhibits the Na+/K+-ATPase enzyme, acting as a sodium pump blocker to increase intracellular sodium and calcium, which enhances cardiac contractility.
Thus, B matches with III.
- C. Captopril: Inhibits Angiotensin-Converting Enzyme, preventing the conversion of angiotensin I to the potent vasoconstrictor angiotensin II.
Thus, C matches with II.
- D. Levcromakalim: Activates ATP-sensitive potassium channels, promoting hyperpolarization of smooth muscle cells and causing vasodilation.
Thus, D matches with I.

Step 3: Final Answer:
Matching these combinations gives: A-IV, B-III, C-II, D-I, which corresponds to option (A).