Question

Match List I with List II 

 

• A. A-IV, B-III, C-II, D-I
• B. A-I, B-II, C-III, D-IV
• C. A-II, B-I, C-IV, D-III
• D. A-III, B-IV, C-II, D-I

Hint:

Furosemide is the classic loop diuretic (C-IV), and Mannitol is the classic osmotic diuretic (B-I).
Identifying these two diagnostic matches is sufficient to select option (C) immediately.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
Diuretics are drugs that promote diuresis (increased urine output) by targeting different segments of the nephron and altering solute and water reabsorption.

Step 2: Detailed Explanation:
Let us match each diuretic with its pharmacological class:
- A. Acetazolamide: Inhibits the enzyme carbonic anhydrase in the proximal convoluted tubule, reducing bicarbonate reabsorption and promoting mild diuresis.
Thus, A matches with II.
- B. Mannitol: A pharmacologically inert solute that is filtered by the glomerulus but not reabsorbed, drawing water into the renal tubules via osmotic pressure.
Thus, B matches with I.
- C. Furosemide: A highly potent diuretic that inhibits the Na+/K+/2Cl- cotransporter in the thick ascending limb of the loop of Henle.
Thus, C matches with IV.
- D. Spironolactone: Competitively inhibits aldosterone binding to mineralocorticoid receptors in the distal tubule and collecting duct, acting as a potassium-sparing diuretic.
Thus, D matches with III.

Step 3: Final Answer:
Matching these pairs gives: A-II, B-I, C-IV, D-III, which corresponds to option (C).