Question

Match List I with List II 

 

• A. A-II, B-IV, C-I, D-III
• B. A-III, B-IV, C-I, D-II
• C. A-I, B-III, C-II, D-IV
• D. A-IV, B-III, C-II, D-I

Hint:

Remember:
- Sorghum $\rightarrow$ Cyanide poisoning (dhurrin).
- Bracken Fern $\rightarrow$ Thiaminase (thiamine deficiency in horses).
- Datura $\rightarrow$ Tropane alkaloids (scopolamine hyoscine).

Answer 1

The Correct Option is B

Step 1: Understanding the Concept:
Veterinary toxicology and pharmacology encompass plant toxins, cellular mechanisms of action, and metabolic pathways utilized by animals to detoxify chemical compounds.

Step 2: Detailed Explanation:
Let us correlate each term from List I with its biological significance in List II:
- A. Hydrogen Cyanide (HCN): Plants of the genus Sorghum (such as Sorghum vulgare) contain the cyanogenic glycoside dhurrin, which is enzymatically hydrolyzed in the rumen to release toxic HCN.
Thus, A matches with III.
- B. Bracken Fern: Bracken Fern (Pteridium aquilinum) contains the enzyme thiaminase, which degrades dietary thiamine in monogastric animals (particularly horses), resulting in clinical thiamine deficiency.
Thus, B matches with IV.
- C. Datura: Plants of the genus Datura (thornapple) are rich in tropane alkaloids, particularly atropine and hyoscine (scopolamine).
Thus, C matches with I.
- D. Acetylation: This is a metabolic conjugation reaction where an acetyl group is transferred to a drug, representing a classic Phase-II drug biotransformation pathway.
Thus, D matches with II.

Step 3: Final Answer:
Matching these pairs gives the sequence A-III, B-IV, C-I, D-II, which is option (B).