Question

Match List I (Cells) with List II (Tumours that develop from them) and select the correct answer using the codes given below the lists.

List I (Cells)	List II (Tumours that develop from them)
A. Leydig cells	1. Carcinoid tumour
B. B cells	2. Medullary carcinoma
C. Parafollicular cells	3. Interstitial cell tumour
D. Argentaffin cells	4. Insulinoma

• A. A-1, B-4, C-2, D-3
• B. A-3, B-2, C-1, D-4
• C. A-1, B-2, C-4, D-3
• D. A-3, B-4, C-2, D-1

Hint:

Match each cell to the tumour that carries its own name, such as interstitial cell tumour for Leydig cells.

Answer 1

The Correct Option is D

Step 1: Recall what each cell type normally does.
Leydig cells (interstitial cells of the testis) make testosterone. B cells are the insulin making cells of the pancreatic islets. Parafollicular cells, also called C cells, sit in the thyroid and make calcitonin. Argentaffin cells are the serotonin storing enterochromaffin cells found mainly in the gut.

Step 2: Match each cell to the tumour named after its own lineage.
A tumour of Leydig cells is called an interstitial cell tumour of the testis, since Leydig cells are also known as interstitial cells. So A matches 3.
A tumour of the pancreatic B cells (beta cells) that secretes excess insulin is called an insulinoma. So B matches 4.
A tumour of the parafollicular C cells of the thyroid is called medullary carcinoma of the thyroid, and it often secretes calcitonin. So C matches 2.
A tumour of the argentaffin (enterochromaffin) cells is called a carcinoid tumour. So D matches 1.

Step 3: Put the matches together.
This gives A-3, B-4, C-2, D-1.

Step 4: Compare with the codes.
Code (a) gives A-1, B-4, C-2, D-3, which is wrong for A and D.
Code (b) gives A-3, B-2, C-1, D-4, which is wrong for B and C.
Code (c) gives A-1, B-2, C-4, D-3, which does not match our derived pairing.
Code (d) gives A-3, B-4, C-2, D-1, which matches our derived answer exactly.

Step 5: Final Answer:
The correct code is (d), that is A-3, B-4, C-2, D-1.