Question

Linseed meal containing limatidine interferes in the utilization of which of the following vitamins?

• A. Thiamin
• B. Pyridoxine
• C. Biotin
• D. Folacin

Hint:

Antinutritional Factors & Vitamin Antagonists:
Linseed meal (Linatine) $\rightarrow$ PYRIDOXINE (Vitamin $\text{B}_6$) Antagonist.
Raw Egg White (Avidin) $\rightarrow$ BIOTIN Antagonist.
Raw Bracken Fern (Thiaminase) $\rightarrow$ THIAMIN Antagonist.

Answer 1

The Correct Option is B

Step 1: Understanding the Concept:
Naturally occurring antinutritional factors: linatine in linseed meal hydrolyzes into 1-amino-D-proline, a potent antimetabolite of pyridoxine (Vitamin B6).
Key Formula or Approach:
\[ \text{Linatine (Linseed Meal)} \xrightarrow{\text{Hydrolysis}} \text{1-Amino-D-Proline} + \text{Glutamic Acid} \xrightarrow{\text{Antagonizes}} \text{Pyridoxine (Vitamin B}_6\text{)} \]

Step 2: Detailed Explanation:
Antinutritional factor in Linseed (Flaxseed) Meal:
- Raw linseed meal contains Linatine (a dipeptide of $\gamma$-glutamyl-1-amino-D-proline).
- In the gastrointestinal tract, linatine is hydrolyzed to release 1-amino-D-proline, which forms a stable hydrazone complex with pyridoxal phosphate (PLP), acting as a powerful competitive antimetabolite of Pyridoxine (Vitamin $\text{B}_6$).
- In poultry and monogastrics fed unheated linseed meal, it induces severe vitamin $\text{B}_6$ deficiency (poor growth, perosis, and convulsions), which is fully reversed by pyridoxine supplementation or water soaking/autoclaving.

Step 3: Final Answer:
Hence, linatine interferes with the utilization of Pyridoxine, corresponding to option (B).