Question

In glycolysis, how much is the net production of ATP/hexose molecule?

• A. 4
• B. 3
• C. 1
• D. 2

Hint:

Glycolysis: Glucose $\rightarrow$ 2 Pyruvate + 2 ATP (net).
Also produces 2 NADH.
ATP yield per glucose under anaerobic conditions: 2 ATP only.

Answer 1

The Correct Option is D

Step 1: Understanding the Concept:
Glycolysis is the metabolic pathway that converts glucose (hexose) into pyruvate.

Step 2: Key Formula or Approach:
Glycolysis produces ATP through substrate-level phosphorylation.

Step 3: Detailed Explanation:
Glycolysis steps with ATP production:
- Investment phase: Uses 2 ATP.
- Payoff phase: Produces 4 ATP.
Net production: 4 ATP - 2 ATP = 2 ATP per hexose molecule.
In addition, 2 NADH molecules are produced (which yield more ATP in oxidative phosphorylation).
Thus, the net ATP production from glycolysis is 2.

Step 4: Final Answer:
Thus, the net production of ATP in glycolysis is 2 per hexose molecule.
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