Question:
IL-1 is activated by which of the following?
IL-1 is activated by which of the following?
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Think inflammasome and the enzyme once called ICE.
Updated On: Jun 23, 2026
- Caspase 1
- Caspase 3
- Caspase 8
- Caspase 5
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The Correct Option is A
Solution and Explanation
Step 1: Interleukin-1 beta (IL-1 beta) is a key pro-inflammatory cytokine that is produced in an inactive precursor form (pro-IL-1 beta) and needs proteolytic cleavage to become active. Step 2: This cleavage is carried out by Caspase-1, which is also called interleukin-1 converting enzyme (ICE). Caspase-1 is activated within the inflammasome complex. Step 3: Once activated, Caspase-1 cleaves pro-IL-1 beta and pro-IL-18 into their mature active forms, which are then secreted to drive the inflammatory response in neighbouring cells. Step 4: Caspase 3 and Caspase 8 are involved in apoptosis (executioner and initiator caspases), not in IL-1 activation, so they are wrong. Hence Caspase 1 is the correct answer.
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