Question

Hepatotoxicity is the major adverse effect of one of the following antitubercular drugs.

• A. Isoniazid
• B. Ethambutol
• C. Pyrazinamide
• D. Rifampicin

Hint:

Isoniazid (INH) = Injury to the Nerve (Peripheral Neuritis) and Hepatocytes (Liver).

Answer 1

The Correct Option is A

Step 1: Concept
Antitubercular therapy involves a combination of drugs, many of which can affect liver function.

Step 2: Meaning
Hepatotoxicity refers to drug-induced liver damage.

Step 3: Analysis
While Pyrazinamide and Rifampicin can also cause liver issues, Isoniazid (INH) is historically and clinically the most significant for causing drug-induced hepatitis, particularly in slow acetylators. Ethambutol is primarily associated with optic neuritis.

Step 4: Conclusion
Isoniazid is the primary antitubercular drug associated with significant hepatotoxicity.

Final Answer: (A)