H1 receptor protein in humans is made up of:
Show Hint
- 487 Aminoacids
- 390 Aminoacids
- 445 Aminoacids
- 359 Aminoacids
The Correct Option is A
Approach Solution - 1
The H1 receptor is a type of histamine receptor found in humans and plays a significant role in various physiological functions, including immune responses and neurotransmission. The H1 receptor protein is a G-protein coupled receptor (GPCR), and it is composed of 487 amino acids. This receptor is involved in mediating the effects of histamine, such as vasodilation and contraction of smooth muscles, which are integral in allergic reactions and inflammation.
Why Other Options Are Incorrect: -
- (B) 390 Aminoacids: This is not the correct number of amino acids for the H1 receptor protein.
- (C) 445 Aminoacids: Although a close number, this is not the correct length of the H1 receptor protein.
- (D) 359 Aminoacids: This is also incorrect for the H1 receptor protein's length.
Thus, the correct answer is 487 amino acids, which is the precise length of the human H1 receptor protein.
Approach Solution -2
The H1 histamine receptor is a G-protein coupled receptor (GPCR) with the typical seven-transmembrane helix architecture. GPCRs in the amine receptor family are usually similar in overall size, so comparing the given values against known GPCR chain lengths helps confirm which one matches H1.
- 487 Aminoacids: The human H1 receptor gene (HRH1) codes for a polypeptide of 487 amino acid residues. This chain length has been confirmed through cloning and sequencing of the receptor, making it the recorded size of the mature H1 receptor protein.
- 390 Aminoacids: This is shorter than typical class A aminergic GPCRs of this kind, which generally run in the mid-400s residue range given their seven-transmembrane domains plus extracellular and intracellular loops and terminal tails, so this figure undercounts the H1 receptor's actual length.
- 445 Aminoacids: While in the right general range for a GPCR of this family, this specific figure does not match H1's confirmed sequence length and is closer to some other aminergic receptors rather than H1 itself.
- 359 Aminoacids: This value is well below the length expected for a seven-transmembrane receptor with the H1 receptor's characteristically long third intracellular loop, which itself adds a substantial number of residues beyond the core transmembrane helices.
Sequencing data for the cloned human H1 receptor gene consistently reports a 487 amino acid protein, distinguishing it from the other candidate lengths.
Therefore, the correct answer is 487 Aminoacids.
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