Question:
Glanzmann thrombasthenia is due to which of the following?
Glanzmann thrombasthenia is due to which of the following?
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Defective fibrinogen receptor blocks platelet aggregation.
Updated On: Jun 23, 2026
- Decreased GpIb
- Decreased GpIIb/IIIa
- Anti-GpIIb/IIIa antibodies
- Inhibition or deficiency of ADAMTS 13
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The Correct Option is B
Solution and Explanation
Step 1: Glanzmann thrombasthenia is an autosomal recessive bleeding disorder of platelet function.
Step 2: It is caused by an inherited deficiency or defect of the platelet membrane glycoprotein IIb/IIIa complex (integrin alpha-IIb-beta-3), which is the fibrinogen receptor needed for platelet-to-platelet aggregation. This makes option (b) correct.
Step 3: Because GpIIb/IIIa is absent, primary platelet aggregation with ADP or collagen fails, giving a prolonged bleeding time with a normal platelet count.
Step 4: Decreased GpIb is the defect in Bernard-Soulier syndrome (a), anti-GpIIb/IIIa antibodies cause immune thrombocytopenia (c), and ADAMTS-13 deficiency causes TTP (d) - none of these are Glanzmann thrombasthenia.
Step 2: It is caused by an inherited deficiency or defect of the platelet membrane glycoprotein IIb/IIIa complex (integrin alpha-IIb-beta-3), which is the fibrinogen receptor needed for platelet-to-platelet aggregation. This makes option (b) correct.
Step 3: Because GpIIb/IIIa is absent, primary platelet aggregation with ADP or collagen fails, giving a prolonged bleeding time with a normal platelet count.
Step 4: Decreased GpIb is the defect in Bernard-Soulier syndrome (a), anti-GpIIb/IIIa antibodies cause immune thrombocytopenia (c), and ADAMTS-13 deficiency causes TTP (d) - none of these are Glanzmann thrombasthenia.
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