Question

Given below are two statements, one is labelled as Assertion A and the other is labelled as Reason R.

Assertion A: Ascaris lumbricoides in swine causes obstructive jaundice.

Reason R: Hemobilirubin is not converted into cholebilirubin.

In light of the above statements, choose the correct answer from the options given below.

• A. Both A and R are true and R is the correct explanation of A.
• B. Both A and R are true but R is NOT the correct explanation of A.
• C. A is true but R is false.
• D. A is false but R is true.

Hint:

In obstructive jaundice, remember the sequence: Bile duct obstruction $\rightarrow$ Bile cannot enter intestine $\rightarrow$ Hemobilirubin is not converted to cholebilirubin $\rightarrow$ Conjugated bilirubin accumulates in blood.

Answer 1

The Correct Option is A

Step 1: Understanding the Concept:
Obstructive jaundice occurs when the flow of bile from the liver to the intestine is blocked.
In swine, adult Ascaris lumbricoides may migrate into the bile duct and produce biliary obstruction, resulting in jaundice.
Detailed Explanation:
Assertion A:
The adult worm may obstruct the common bile duct, preventing the normal passage of bile into the intestine.
This leads to accumulation of conjugated bilirubin in blood and produces obstructive jaundice.
Therefore, Assertion A is true.
Reason R:
Hemobilirubin (conjugated bilirubin present in bile) normally enters the intestine, where bacterial action converts it into cholebilirubin and subsequently other bile pigments.
When the bile duct is obstructed, hemobilirubin cannot reach the intestine and is therefore not converted into cholebilirubin.
Thus, Reason R is true.

Step 2: Relationship between Assertion and Reason:
The obstruction produced by Ascaris prevents bile from reaching the intestine, thereby stopping the conversion of hemobilirubin into cholebilirubin.
Hence, the Reason correctly explains the biochemical basis of the Assertion.

Step 3: Final Answer:
Both Assertion A and Reason R are true, and Reason R is the correct explanation of Assertion A.
\[ \boxed{(A) Both A and R are true and R is the correct explanation of A. \]