Question:
Filgrastim is used in the treatment of:
Filgrastim is used in the treatment of:
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It is recombinant G-CSF, so it boosts the neutrophil line.
Updated On: Jun 23, 2026
- Anemia
- Neutropenia
- Malaria
- Filarial
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The Correct Option is B
Solution and Explanation
Step 1: Filgrastim is a recombinant human granulocyte colony-stimulating factor (G-CSF), a 175-amino-acid glycoprotein.
Step 2: G-CSF stimulates the proliferation and differentiation of neutrophil precursors and the release of mature neutrophils from the marrow. This makes filgrastim effective in treating severe neutropenia, such as chemotherapy-induced neutropenia.
Step 3: It differs from natural G-CSF by lacking glycosylation and carrying an extra N-terminal methionine, but its function in raising the neutrophil count is preserved.
Step 4: Anemia is treated with erythropoietin, not G-CSF. Malaria and filariasis are infections treated with antiparasitic drugs, not colony-stimulating factors. Hence neutropenia is the correct answer.
Step 2: G-CSF stimulates the proliferation and differentiation of neutrophil precursors and the release of mature neutrophils from the marrow. This makes filgrastim effective in treating severe neutropenia, such as chemotherapy-induced neutropenia.
Step 3: It differs from natural G-CSF by lacking glycosylation and carrying an extra N-terminal methionine, but its function in raising the neutrophil count is preserved.
Step 4: Anemia is treated with erythropoietin, not G-CSF. Malaria and filariasis are infections treated with antiparasitic drugs, not colony-stimulating factors. Hence neutropenia is the correct answer.
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