Step 1: Understanding the Concept:
The accidental discovery of Bordeaux mixture by Pierre-Marie-Alexis Millardet in 1882 revolutionized chemical plant protection.
Step 2: Detailed Explanation:
Historical context of grapevine downy mildew (Plasmopara viticola):
- Phylloxera-resistant wild American rootstocks imported into France inadvertently introduced the downy mildew pathogen (Statement D).
- Professor Millardet observed that vines along roadsides sprayed with a mixture of copper sulfate and lime to deter pilferers remained healthy, marking the historic accidental discovery of the first chemical fungicide, Bordeaux mixture.
In this historical context, the combination A, D, E represents the designated option.
Step 3: Final Answer:
Therefore, the correct answer is A, D, E only.