Question:
Choose the best method of diagnosis for the clinical sign represented in the image.
Choose the best method of diagnosis for the clinical sign represented in the image.
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The corneal ring points to Wilson disease, so test the copper-carrying protein.
Updated On: Jun 24, 2026
- Serum copper
- Serum ceruloplasmin
- Karyotyping
- PCR
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The Correct Option is B
Solution and Explanation
Step 1: The image shows a Kayser-Fleischer ring, a golden-brown ring at the corneal periphery caused by copper deposition in Descemet's membrane. Step 2: This sign is characteristic of Wilson's disease, an autosomal recessive disorder of copper metabolism. Step 3: The best screening and diagnostic test among the options is serum ceruloplasmin, which is the copper-carrying ferroxidase and is characteristically low in Wilson's disease (part of Sternlieb's criteria along with KF rings, raised hepatic copper and increased 24-hour urinary copper). Step 4: Serum copper alone is unreliable because free copper rises while total copper may fall, and karyotyping or PCR are not used to diagnose this metabolic condition. Hence serum ceruloplasmin is correct.
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