Question:

ATP is produced in which of the following steps of ETS?

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The three phosphorylation sites of the respiratory chain are:
1. NADH \(\rightarrow\) CoQ
2. Cyt b \(\rightarrow\) Cyt c
3. Cyt a \(\rightarrow\) \(O_2\)
  • FAD-UQ
  • Cyt_b-Cyt_c
  • Cyt_c-Cyt_c1
  • Cyt_a-Cyt_c
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The Correct Option is B

Solution and Explanation

Step 1: Understanding the Concept:
During mitochondrial respiration, the electron transport chain (ETC) transfers electrons through a series of complexes.
This transfer is coupled with the pumping of protons across the inner mitochondrial membrane, generating a proton gradient that drives ATP synthesis (oxidative phosphorylation).

Step 3: Detailed Explanation:

There are three classical coupling sites in the mitochondrial electron transport chain where the free energy change of electron transfer is sufficient to drive ATP synthesis:
- Site I: Transfer of electrons from NADH to Coenzyme Q (Ubiquinone, UQ).
- Site II: Transfer of electrons from Cytochrome b to Cytochrome c (via Complex III).
- Site III: Transfer of electrons from Cytochrome a to molecular oxygen (via Complex IV).
Among the given options, the step from Cytochrome b to Cytochrome c (Cyt_b-Cyt_c) corresponds to Site II of ATP synthesis.

Step 4: Final Answer:

ATP is produced during the Cyt_b-Cyt_c step, which corresponds to option (B).
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