Question:
An anticoccidial that may be effective against bovine tropical theileriosis is:
An anticoccidial that may be effective against bovine tropical theileriosis is:
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The two major drugs used against Bovine Theileriosis are Buparvaquone (the gold standard feeding drug) and Halofuginone lactate (an anticoccidial derivative). Keep this pair in mind for pharmacology questions.
Updated On: Aug 13, 2026
- Amprolium
- Salinomycin
- Halofuginone
- Monensin
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The Correct Option is C
Solution and Explanation
Step 1: Understanding the Concept:
Bovine tropical theileriosis, caused by the intracellular apicomplexan parasite Theileria annulata, is a highly fatal disease of cattle.
Specific therapeutic agents are required to target the schizont and piroplasm stages of the parasite.
Interestingly, certain chemical classes developed as anticoccidials also exhibit potent activity against other apicomplexan parasites like Theileria.
Step 2: Detailed Explanation:
Let us evaluate the therapeutic properties of the given options:
1. Amprolium:
Amprolium is a thiamine analogue used as an anticoccidial in poultry and calves.
It works by blocking thiamine uptake in Eimeria.
It does not have any therapeutic activity against Theileria.
2. Salinomycin and Monensin:
These are polyether ionophore antibiotics widely used as feed-additive anticoccidials and growth promoters in ruminants and poultry.
They act by disrupting ionic transport across cell membranes.
They are not used to treat systemic theileriosis infections in cattle.
3. Halofuginone:
Halofuginone is a quinazolinone derivative that was originally developed as an oral anticoccidial for poultry.
Research and clinical trials demonstrated that Halofuginone lactate possesses strong antitheilerial properties.
It is highly effective against both Theileria annulata and Theileria parva, targeting the pathogenic schizont stage in host lymphocytes.
It is used clinically in several endemic regions to treat bovine tropical theileriosis, especially in combination with supportive therapy.
Therefore, this option is correct.
Step 3: Final Answer:
The anticoccidial agent with proven therapeutic efficacy against Theileria annulata in cattle is Halofuginone.
Therefore, the correct answer is option (C).
Bovine tropical theileriosis, caused by the intracellular apicomplexan parasite Theileria annulata, is a highly fatal disease of cattle.
Specific therapeutic agents are required to target the schizont and piroplasm stages of the parasite.
Interestingly, certain chemical classes developed as anticoccidials also exhibit potent activity against other apicomplexan parasites like Theileria.
Step 2: Detailed Explanation:
Let us evaluate the therapeutic properties of the given options:
1. Amprolium:
Amprolium is a thiamine analogue used as an anticoccidial in poultry and calves.
It works by blocking thiamine uptake in Eimeria.
It does not have any therapeutic activity against Theileria.
2. Salinomycin and Monensin:
These are polyether ionophore antibiotics widely used as feed-additive anticoccidials and growth promoters in ruminants and poultry.
They act by disrupting ionic transport across cell membranes.
They are not used to treat systemic theileriosis infections in cattle.
3. Halofuginone:
Halofuginone is a quinazolinone derivative that was originally developed as an oral anticoccidial for poultry.
Research and clinical trials demonstrated that Halofuginone lactate possesses strong antitheilerial properties.
It is highly effective against both Theileria annulata and Theileria parva, targeting the pathogenic schizont stage in host lymphocytes.
It is used clinically in several endemic regions to treat bovine tropical theileriosis, especially in combination with supportive therapy.
Therefore, this option is correct.
Step 3: Final Answer:
The anticoccidial agent with proven therapeutic efficacy against Theileria annulata in cattle is Halofuginone.
Therefore, the correct answer is option (C).
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