Question:
All of the following immunohistochemical markers are positive in the neoplastic cells of granulocytic sarcoma, except:
All of the following immunohistochemical markers are positive in the neoplastic cells of granulocytic sarcoma, except:
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Three options are myeloid markers; which one is a T-cell marker?
Updated On: Jun 24, 2026
- CD45 RO
- CD43
- Myeloperoxidase
- Lysozyme
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The Correct Option is A
Solution and Explanation
Step 1: Granulocytic sarcoma, also called chloroma or myeloblastoma, is a solid extramedullary tumour made up of myeloblasts. It is an extramedullary manifestation of acute myeloid leukaemia (AML) and is most common with monocytic differentiation (M4 and M5 subtypes). The greenish tint of the tumour is due to myeloperoxidase.
Step 2: Because the cells are of myeloid lineage, they express myeloid markers. Granulocytic sarcoma is positive for myeloperoxidase, lysozyme, CD43, CD68, CD117 and CD34. So options CD43, myeloperoxidase and lysozyme are all expected to be positive.
Step 3: CD45 RO is a marker of T lymphocytes (a T-cell or leukocyte isoform marker), not of myeloid blasts. Therefore the neoplastic cells of granulocytic sarcoma do not stain for CD45 RO.
Step 4: Since the question asks for the exception, the marker that is NOT positive is CD45 RO.
Step 2: Because the cells are of myeloid lineage, they express myeloid markers. Granulocytic sarcoma is positive for myeloperoxidase, lysozyme, CD43, CD68, CD117 and CD34. So options CD43, myeloperoxidase and lysozyme are all expected to be positive.
Step 3: CD45 RO is a marker of T lymphocytes (a T-cell or leukocyte isoform marker), not of myeloid blasts. Therefore the neoplastic cells of granulocytic sarcoma do not stain for CD45 RO.
Step 4: Since the question asks for the exception, the marker that is NOT positive is CD45 RO.
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