Question

All of the following are true about xanthogranulomatous inflammation EXCEPT:

• A. Presence of foamy macrophages
• B. Presence of tuberculous infection
• C. Presence of multinucleated giant cells
• D. Presence of yellow nodules

Hint:

This lipid-laden yellow inflammation is driven by pyogenic bacteria like Proteus, not by TB.

Answer 1

The Correct Option is B

Step 1: Understand xanthogranulomatous inflammation. It is a special form of chronic destructive inflammation characterised by collections of lipid-laden foamy macrophages, mixed with other inflammatory cells, often forming yellowish masses. The classic sites are xanthogranulomatous pyelonephritis and xanthogranulomatous cholecystitis.
Step 2: Check option A. Foamy (lipid-laden) macrophages are the histological hallmark. TRUE.
Step 3: Check option D. The lipid content gives the lesion its characteristic yellow colour and yellow nodules grossly. TRUE.
Step 4: Check option C. Multinucleated giant cells can be present within the granulomatous mixed inflammatory infiltrate. TRUE.
Step 5: Check option B. Xanthogranulomatous pyelonephritis is typically associated with chronic obstruction and infection by bacteria such as Proteus and Escherichia coli, NOT with tuberculosis. Tuberculous infection is not a feature. FALSE.
Step 6: Select the exception. The incorrect statement is the presence of tuberculous infection.
Answer: Presence of tuberculous infection (option B) is FALSE.