Question

A polyketide that inhibits the enzyme ATP synthase by blocking the movement of protons through its Fo unit is:

• A. Oligomycin
• B. Thermogenin
• C. Dicumarol
• D. Demerol

Hint:

Oligomycin:
- Blocks proton flow through Fo.
- Inhibits ATP synthesis.
- Other inhibitors: DCCD (also blocks Fo).

Answer 1

The Correct Option is A

Step 1: Understanding the Question:
This question tests knowledge of inhibitors of oxidative phosphorylation.

Step 2: Detailed Explanation:
Oligomycin is a polyketide antibiotic that inhibits ATP synthase.
It binds to the Fo unit of ATP synthase and blocks the proton channel.
This prevents proton flow and inhibits ATP synthesis.
Thermogenin (B): Uncoupling protein (dissipates proton gradient).
Dicumarol (C): Uncoupler (dissipates proton gradient).
Demerol (D): An analgesic (not an ATP synthase inhibitor).
Thus, oligomycin is the correct answer.

Step 3: Final Answer:
Thus, oligomycin inhibits ATP synthase by blocking proton movement through Fo, which corresponds to option (A).
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