Question:
A patient with history of cough, chest pain, and dyspnea has imaging that reveals giant cell granuloma formation and stellate inclusions. What is the likely diagnosis?
A patient with history of cough, chest pain, and dyspnea has imaging that reveals giant cell granuloma formation and stellate inclusions. What is the likely diagnosis?
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Non-caseating granulomas with asteroid bodies or Schaumann bodies = sarcoidosis.
Updated On: Aug 27, 2026
- Tuberculosis
- Sarcoidosis
- Lung cancer
- Fungal infection
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The Correct Option is B
Solution and Explanation
Concept:
Sarcoidosis is a multisystem granulomatous disease characterized by non-caseating granulomas. Histology may show giant cells with asteroid bodies or Schaumann bodies.
Step 1: Identify granuloma type.
The question mentions giant cell granuloma formation. Sarcoidosis commonly shows non-caseating granulomas.
Step 2: Identify inclusions.
Stellate inclusions are asteroid bodies seen within giant cells in sarcoidosis.
Step 3: Select the diagnosis.
Pulmonary symptoms with granulomas and stellate inclusions point toward: \[ \text{Sarcoidosis} \] Therefore, the correct answer is Sarcoidosis.
Step 1: Identify granuloma type.
The question mentions giant cell granuloma formation. Sarcoidosis commonly shows non-caseating granulomas.
Step 2: Identify inclusions.
Stellate inclusions are asteroid bodies seen within giant cells in sarcoidosis.
Step 3: Select the diagnosis.
Pulmonary symptoms with granulomas and stellate inclusions point toward: \[ \text{Sarcoidosis} \] Therefore, the correct answer is Sarcoidosis.
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