Question:

A female horse (2n = 66) can be crossed with a jackass (2n = 66), resulting in tire birth of a hybrid known as a mule, usually sterile because of chromosomal incompatibility. How many chromosomes would one expect to find in the body cells f a mule?

Updated On: Mar 26, 2024
  • 66
  • 33
  • 132
  • a variable number
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The Correct Option is A

Approach Solution - 1

66 chromosomes present in hybrid mule is the result of n = 33 of female horse and n = 33 of jackass.
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Approach Solution -2

Explanation: 

A female horse has 64 chromosomes (2n = 64), and a jackass has 62 chromosomes (2n = 62) as well.

  • A mule is the offspring of a horse and a donkey.
  • Since a mule is a hybrid, it inherits one set of chromosomes from its horse parent and one set from its donkey parent.
  • Therefore, a mule would have 32 chromosomes from the horse parent + 31 chromosomes from the donkey parent.
  • Hence, 32+31=63. 
  • Which is an odd number of chromosomes so the offspring has many disrupted body functions. One of which is sterility.

Thus, the right answer to this question is 63.

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Concepts Used:

Principles of Inheritance and Variation - Mutation

A Mutation is a change in the sequence of our DNA base pairs caused by numerous environmental stimuli such as UV light or mistakes during DNA replication. Germline mutations take place in the eggs and sperm and can be passed onto offspring, whereas somatic mutations take place in body cells and are not passed on.

Types of Mutations

There are three types of mutations, which are as follows:

Silent mutation

It refers to any change in DNA sequence that has no effect on the amino acid sequence in a protein or the functions that a protein performs. There is no phenotypic indication that a mutation has occurred.

Nonsense mutation

When there is a change in the sequence of base pairs due to a point mutation, that results in a stop codon. This leads to a protein that is either shortened or non-functional.

Missense mutation

A missense mutation occurs when a point mutation causes a change in the codon, which then codes for another amino acid.

The mutation is caused by the following factors:

Internal Causes

When DNA copies incorrectly, the majority of mutations occur. Evolution occurs as a result of all of these mutations. DNA makes a copy of itself during cell division. When a copy of DNA isn't flawless, it's called a mutation since it differs somewhat from the original DNA.

External Causes

When certain chemicals or radiations are used to break down DNA, it causes the DNA to break down. The thymine dimers are broken by UV radiation, resulting in altered DNA.