Bachelor of Engineering [B.Eng] [Mechanical Engineering] From University of Brighton

The Quantitative Structure/skin-permeation Relationships (QSPeRs) project is offered by the University of Bradford.

The transdermal route has many advantages over other routes for the delivery of drugs with systemic activity. These include the ease of use (and withdrawal in the occurrence of side-effects), avoidance of first-pass metabolism, and improved patient compliance. The assessment of percutaneous absorption of molecules is a very important step in the evaluation of any transdermal drug delivery system.

However, such studies are virtually impossible due to ethical difficulties and high cost, particularly during the early stage of new drug candidate development. Hence the development of reliable quantitative structure/skin-permeation relationships (QSPeRs) which predict precisely transdermal delivery is of great interest and importance in industrial, regulatory, and academic circles [1]. It is also of great importance to find formulation strategies to improve skin permeability for poorly permeable drugs.Quantitative structure/skin permeation relationships (QSPeRs) relate the experimentally determined percutaneous penetration of exogenous chemicals to known physicochemical parameters using standard statistical methods. QSPeRs provide insights into permeation mechanisms, can predict the permeation of novel compounds even when they exist only on paper, and reduce or eliminate the need for in vivo experiments.